Aim: This work was done to study the effect 
                              of vitamin A, E and Se with varying sexual rest 
                              period in cross-bred cows with chronic 
                              endometritis. 
              
                              
              Materials and Methods: 
                              Cross-bred cows (n=396) from different villages of 
                              West Bengal with purulent or muco-purulent 
                              discharge with a history of infertility and repeat 
                              breeding for 3 to 6 months were chosen for the 
                              present study. These cows received uterine wash 
                              with lugol's iodine, intra-uterine and parenteral 
                              antibiotics and de-worming as general treatment. 
                              They were then divided into six groups viz. SR12 × 
                              EV (n=59), SR12 × Control (n=67), SR21 × EV 
                              (n=65), SR21 × Control (n=70), SR24 × EV (n=66), 
                              SR24 × Control (n=69) receiving sexual rest of 12 
                              (SR12), 21 (SR21) and 24 (SR24) days with (EV 
                              group) or without (control) estradiol + vitamin A, 
                              E and Se. 
              
                              
              Results: The results indicate 
                              that the recovery rate of EV and control group was 
                              76.27 % and 37.31 % respectively (P<0.01) in SR 
                              12, 72.31 % and 47.14 % respectively (P<0.01) in 
                              SR 21 and 92.41 % and 63.77 % respectively 
                              (P<0.01) in SR 24. SR 24 showed significantly 
                              better (P<0.01) recovery rate compared to SR 12 
                              and SR 21. Lowest recovery and conception rate of 
                              EV and control group in SR 12 might be due to 
                              insufficient time for the recovery of endometrium. 
              
              
                              
                              Conclusion: The results indicate that 
                              parenteral and intra-uterine antibiotics had 
                              synergistic effect with estradiol, vitamin A, E 
                              and Se treatment in recovery from endometritis, 
                              though a minimum time interval is required for 
                              complete recovery of the endometrium for best 
                              conception rate. 
              
                              
              Keywords: endometritis, 
                              estradiol, progesterone, selenium, sexual rest, 
                              vitamin A, vitamin E